THC Associated with Increase of Survival Time in Palliative Cancer

THC Associated with Increase of Survival Time in Palliative Cancer

Summary from the official government website (Link Below)

The Use of Tetrahydrocannabinol Is Associated with an Increase in Survival Time in Palliative Cancer Patients: A Retrospective Multicenter Cohort Study

The study, conducted by researchers in Germany, analyzed data from the palliative treatment documentation of over 9,000 patients from five ambulatory palliative care teams. The researchers divided the patients into three groups: those who did not receive THC, those who received a low dose of THC (less than or equal to 4.7mg per day), and those who received a higher dose of THC (greater than or equal to 4.7mg per day). They then compared survival rates between the groups.

The analysis revealed that THC use was associated with a statistically significant increase in survival time, but only for patients who received a daily dose exceeding the median amount of 4.7mg. In this group, patients lived an average of 15 days longer compared to those who did not receive THC.

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Key takeaway: This study suggests that THC may offer a survival benefit for ambulatory palliative care patients, but only at higher doses. More research is needed to confirm these findings and to explore the underlying mechanisms.

Additional considerations:

  • The study was observational and cannot definitively prove that THC caused the observed increase in survival time. Other factors may have played a role.
  • The optimal dosage of THC for palliative care patients is still being investigated.
  • THC use can have side effects, and it is important to weigh the potential risks and benefits when considering it as a treatment option.

Further readings:

Source: NIH

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Climate and Health Adaptation Program

You must save yourself from yourself.

Meet MICHAP

Our Vision: Michigan’s public health system fosters equitable health and wellbeing as it adapts to the current and future impacts of climate change.

Our Mission: The Michigan Climate and Health Adaptation Program (MICHAP) supports a climate resilient public health system by investigating climate-driven health risks, identifying information for decision-making across sectors, and collaboratively implementing climate adaptation strategies.

MiCHAP Funding Cycles Infographic

Michigan’s new growth plan: Sacrifices must be made for the environment and team.

Last week Michigan Chief Growth Officer Hilary Doe described immigration as the green line in Michigan’s population story, the one number going up, besides prices, inflation, real estate, groceries, taxes, fees, fees for fees, convience fees, registrations, regulatory fees, utilities, interest rates, school loans, etc, etc, etc.

But A SEMCOG report last year found that 14,012 people aged 64 or younger left Southeast Michigan each year between 2010 and 2019, while 14,737 foreigners arrived annually. It’s 2024. It’s a stunning and brave new world – who cares about 2010-2019.

Statewide, immigration “helps offset our out-migration a little bit,” Doe said.

Doh is right… A little bit? Why are they leaving a climate haven is the question and why all of the sudden are Michigan citizens asked to let strangers into their homes to live.

Yes “sponsor” a family. Let’s start at your house.

 

In 2020, Gov. Gretchen Whitmer created the Office of Global Michigan.

And now that office is asking Michiganders to ignore common sense and serve as sponsors to refugees. Sounds like a win win.

Read more about that here and below

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The Division of Environmental Health (DEH) uses the best available science to reduce, eliminate, or prevent public health harm from environmental, chemical, and physical hazards. Learn more about DEH

***If You believe you are in immediate danger, call 911 or Contact Poison Control at 800-222-1222.

For less urgent concerns, call the MDHHS Toxicology and Environmental Health hotline at 800-648-6942, Monday through Friday between 8 a.m. and 5 p.m.

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Feds discover new methods to distinguish hemp and marijuana to assist crime labs

Feds discover new methods to distinguish hemp and marijuana to assist crime labs

Federally funded researchers have uncovered two methods to divide and diversify the difference between hemp and cannabis to assist to crime labs. 

Because Cannabis is still a crime and Hemp is not…

The Controlled Substance Act of 1970 classified the plant cannabis, which was historically classified as either marijuana or hemp, as an illegal drug, a Schedule I controlled substance with a high potential for abuse and no FDA-approved medical use in the United States.

For more than 50 years, hundreds of thousands of people were arrested and imprisoned for possessing it.

317,793 Americans are arrested annually for possession of marijuana. Easy Target – Easy Money.

The Farm Bill of 2018 changed this straightforward classification of cannabis. The bill legalized the form of cannabis classified as hemp, while the form classified as marijuana remained illegal.

The task of determining the distinction has been assigned to law enforcement and forensic laboratories, a responsibility that has proven to be challenging, time-consuming, and costly.

Federally funded researchers have made significant advancements in accurately distinguishing between marijuana and hemp by precisely analyzing the THC levels found in flower and edibles.

The National Institute of Justice (NIJ), an entity within the “Justice” Department, is actively promoting the results of two research projects that it funded, both centered around cannabis lab testing. These findings are now being shared exclusively with select law enforcement agencies.

The aim of the initiatives was to streamline the testing process in order to address the increasing crime lab backlogs caused by the federal legalization of hemp with up to 0.3 percent THC under the 2018 Farm Bill.

This legalization has complicated cannabis-related cases, and thus the initiatives were implemented to help resolve these challenges.

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Current testing methods are unable to accurately determine the exact amount of THC in a sample, as stated in the recent update by NIJ. However, the researchers they have funded have achieved a significant breakthrough.

Using gas chromatography-mass spectrometry (GC-MS) and direct analysis in real time-high-resolution mass spectrometry (DART-HRMS), they are now able to isolate the THC content, along with other cannabinoids.

This discovery marks a significant advancement in our ability to analyze and understand the composition of cannabis samples.

In the government, everything is go spend more money and if that doesn’t work, it’s go spend more money and if that doesn’t work spend more money and so on and so on.

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Forensic Science Division – DNA Profiling System

Forensic Science Division – DNA Profiling System

The Michigan State Police Forensic Science Division (FSD) DNA Profiling System is a comprehensive program that uses DNA analysis to support criminal investigations throughout the state. The system is housed within the Biometrics and Identification Division (BID), which was formed in 2011 to consolidate the MSP’s forensic resources and expertise.

The FSD DNA Profiling System is comprised of three main components:

DNA laboratories: The MSP operates seven regional forensic laboratories across the state, each of which is equipped to conduct DNA analysis. These laboratories are staffed by highly trained forensic scientists who use cutting-edge technology to extract, analyze, and interpret DNA evidence.

Combined DNA Index System (CODIS): CODIS is a national database that stores DNA profiles from convicted offenders, unsolved crime scenes, and missing persons. The MSP’s CODIS laboratory compares DNA evidence from crime scenes to profiles in the CODIS database to identify suspects or link crimes together.

DNA Database Unit: The DNA Database Unit is responsible for collecting and storing DNA samples from convicted offenders and felony arrestees, as required by state law. The unit also manages the MSP’s CODIS program and provides training and support to law enforcement agencies throughout Michigan.

The FSD DNA Profiling System has been instrumental in solving a wide range of crimes, from homicides and sexual assaults to burglaries and robberies.

In 2020, the MSP’s DNA laboratories processed over 10,000 DNA samples and made over 1,200 CODIS matches.

The FSD DNA Profiling System is a valuable tool for law enforcement in Michigan. It helps to identify suspects, solve crimes, and bring criminals to justice. The system is also a powerful deterrent to crime, as criminals know that their DNA may be used to identify them if they are caught.

Here are some additional details about the FSD DNA Profiling System:

  • The system is accredited by the American Society of Crime Laboratory Directors (ASCLD/LAB).
  • The system is funded by a combination of state and federal grants.
  • The system is available to all law enforcement agencies in Michigan.

Here are the rules

DEPARTMENT OF STATE POLICE  

FORENSIC SCIENCE DIVISION  

DNA PROFILING SYSTEM

(By authority conferred on the department of state police by section 3 of 1990 PA  
250, MCL 28.173) 

R 28.5051 Definitions.  

Rule 1. As used in these rules:  
(a) “CODIS” means the federal bureau of investigation’s combined DNA Index  
System.  
(b) “Offender” means an individual who is required to provide a DNA sample for a  
qualifying offense at arrest or upon conviction or a finding of responsibility under  
1931 PA 328, MCL 750.520m and 1990 PA 250, MCL 28.176(1) or any other applicable  
law.  
(c) “Sample” means a source of cellular DNA that is collected using the DNA  
collection kit provided by the department.  
(d) “Upon conviction” means within a reasonable time after conviction and  
sentencing or disposition, but before the offender’s release or transfer from state or county custody, as applicable.  
(e) “At arrest” means within a reasonable time after arrest, typically during the  
booking process.  
(f) “Designated agency” means the law enforcement agency that is  
responsible for the sample collection and transmittal of the sample to the department.  
(g) “DNA” means deoxyribonucleic acid, the heredity material contained in nuclear 
cells.  
(h) “Department” means the Michigan department of state police.  
(i) “Qualifying offense” means those offenses for which an individual provides a  
sample for DNA testing as required by law at arrest, upon conviction, or upon a  
finding of responsibility.  
(j) “Profile” means the results of the DNA identification profiling of a sample,  
including a paper, electronic, or digital record.  

R 28.5052 Applicability.

Rule 2. These rules apply to the collecting of samples from the following individuals:

(a) Offenders who are arrested for a qualifying offense under 1931 PA 328, MCL  
750.520m(1)(a).  
(b) Offenders who are convicted of a qualifying offense under 1990 PA 250, MCL  
28.176(1)(b).
(c) Offenders who are prisoners and have not already provided a sample as  
required by 1953 PA 232, MCL 791.233d(1) that meets the requirements of these rules.  
(d) Juvenile offenders who are found responsible for a qualifying offense under  
1990 PA 250, MCL 28.176(1)(a) and 1939 PA 288, MCL 712A.18k.  
(e) Juvenile offenders who are under the supervision of the state department or  
county juvenile agency under 1988 PA 73, MCL 803.225a and have not already  
provided a sample that meets the requirements of these rules.  
(f) Juvenile offenders who are public wards under 1974 PA 150, MCL  
803.307a(1) and have not already provided a sample that meets the  
requirements of these rules.

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 28.5053 Responsibility for collecting samples.  

Rule 3.

(1) The departmentshall provide DNA collection kits to eachdesignated agency. Each designated agency shall contact the department to order DNA collection kits. Each agency shall designate a point of contact correspond with the department regarding matters concerning DNA collection. Each agency shall notify the department of the designated point of contact’s name, address, and telephone number at which the department may direct correspondence to the point of contact regarding matters concerning DNA collection. If the designated point of contact has an e-mail address, the address shall also be provided to the department.

(2) DNA collection kits shall be only used for collecting samples from offenders.  
DNA collection kits shall not be used to collect evidentiary samples for submission in criminal cases.

(3) The designated agency shall provide gloves to the individual performing  
the collection. The individual performing the collection shall wear gloves at all times while performing sample collection and packaging.

(4) Each designated agency shall determine if a DNA sample is already on file for  
the offender through the criminal history record. DNA samples shall not be collected when the criminal history record indicates a DNA sample has previously been obtained from the offender.

(5) If a determination is made that sample collection from the offender is required,  
then the following shall apply as to the designated agencies:

(a) When applicable law requires sample collection upon arrest of an offender,  
the investigating law enforcement agency is the designated agency. The collection of a sample from the offender and transmittal of the sample to the department shall be completed within 30 days of the arrest.  
(b) When applicable law requires sample collection upon conviction or a finding  
of responsibility, unless otherwise ordered by the court, the investigating law  
enforcement agency is the designated agency. If the designated investigating law  
enforcement agency does not collect a sample from the offender within 15 days of conviction or finding of responsibility, the county sheriff is then the designated agency for collection unless otherwise ordered by the court. If a sample has not already been collected, collection of a sample from the offender and transmittal of the sample to the department shall occur before any transfer or release of the offender, whatever the terms of incarceration. If theoffender will be incarcerated for more than 30 days, the collection of a sample from the offender and transmittal of the sample to the department shall be completed within 30 days of the conviction or finding of responsibility.

(c) When applicable law requires sample collection before release from serving a term of incarceration in a facility under the control of the county sheriff, the county sheriff is the designated agency. If a sample has not already been collected, collection of a sample from the offender and transmittal of the sample to the department shall occur before any transferor release of the offender, whatever the term of incarceration. If the offender will be incarcerated for more than 90 days, the collection of a sample from the offender and transmittal of the sample to the department shall be completed 90 days prior to the offender’s release.

(d) When applicable law requires sample collection from an offender and the offender is transferred into a facility under the control of the Michigan department of corrections to serve a term of incarceration, the Michigan department of corrections is the designated agency. If the sample has not already been collected, collection of a sample from the offender and transmittal of the sample to the department shall occur before release of the offender, whatever the term of incarceration. If the offender will be incarcerated for more than 90 days, the collection of a sample from the offender and transmittal of the sample to the department shall be completed within 90 days of receipt of the offender into the facility.

(e) When applicable law requires sample collection from an offender and the offender is serving a term of incarceration in a facility under the control of the Michigan department of corrections, the Michigan department of corrections is the designated agency. If a sample has not already been collected, collection of a sample from the offender and transmittal of the sample to the department shall occur before release of the offender, whatever the term of incarceration. If the offender will be incarcerated for more than 1 year, the collection of a sample from the offender and transmittal of the sample to the department shall be completed a minimum of 1 year prior to the offender’s release.

(f) When applicable law requires sample collection from an offender and the offender is placed under the supervision of a state department or county juvenile agency or is declared a public ward, the investigating law enforcement agency is the designated agency. Collection of a sample from the offender and transmittal of the sample to the department shall occur before any transfer or discharge from wardship, whatever the term of supervision. If the offender will be under supervision for more than 30 days, the collection of a sample from the offender and transmittal of the sample to the department shall be completed within 30 days of the offender being placed under supervision.

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R 28.5054 Procedures for sample collection.

Rule 4.

(1) An offender shall be positively identified by the designated agency or its designee before the samples are taken. The state identification number associated with the offender, if there is an assigned state identification number, shall be used for this purpose and recorded in the specified area on the DNA collection card.  

(2) After the offender is positively identified, the designated agency shall collect  
samples from the offender according to the collection instructions included in the  
DNA collection kit. The sample collection shall be performed by the designated agency  
or its designee; however, the designee shall not be the offender. The designated agency  
shall provide gloves to the individual performing the collection. The individual  
performing the collection shall wear gloves at all times while performing sample  
collection and packaging.

(3) Only the DNA collection kit provided by the department shall be used to collect  
samples. 

(4) The DNA collection card shall be completed by the designated agency prior to  
beginning sample collection. All relevant information requested on the DNA collection  
card shall be provided. The DNA collection card shall bear the fingerprint impressions  
of the offender’s thumbs in the spaces indicated on the DNA collection card.

(5) The collecting, labeling, storing, handling, and transmitting of the samples  
collected shall comply with the collection instructions included in the DNA collection  
kit. Within 72 hours of sample collection, the DNA collection kit shall be transmitted  
to the department by hand delivery, U.S. Mail, or certified carrier.

R 28.5055 Profile record storage and access.

Rule 5.

(1) The national DNA database system “CODIS” shall be used to file, catalog, retrieve, and compare DNA profiles.

(2) Access and use of the CODIS system shall be in accordance with federal law, memorandum of understanding with the federal bureau of investigation for participation in CODIS, all applicable CODIS rules, polices or procedures, and any licensing agreements established by the United States government.

R 28.5056 Privacy protection.

Rule 6.

The results of the DNA profiling shall be disclosed only as provided in 1990 PA 250, MCL 28.176(2).

R 28.5057 Authorized use.

Rule 7.

The department shall only use samples and/or test results for the purposes provided in 1990 PA 250, MCL 28.175a (the DNA IDENTIFICATION PROFILING SYSTEM ACT).

R 28.5058 Disposal of samples and profiles.

Rule 8.

A sample or profile shall not be disposed of if the department determines the individual has otherwise become obligated to submit a sample or if the disposal of the sample would destroy sample or data relating to another individual who would otherwise be retained.

If the sample is eligible for disposal, the sample shall be disposed of in the following instances:

(a) Disposal is ordered by a court of proper jurisdiction in accordance with 1990 PA 250, MCL 28.176(10).

(b) The department receives awritten request for disposal from the investigating police agency or prosecutor in accordance with 1990 PA 250, MCL 28.176(11).

(c) The department receives a written request for disposal and a certified copy of a final court order in accordance with 1990 PA 250, MCL 28.176(11)(b).

R 28.5059 Effect of noncompliance with rules.

Rule 9.

The uploading of DNA profiles into the state DNA database may be denied if the designated agency fails to comply with these rules.

SOURCE FOR RULES:  Courtesy of www.michigan.gov/orr

Current PDF

Don’t forget to always check for updates if you are going to use this information for legal purposes and you should probably consult a lawyer.

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Researchers at Washington State University (WSU) have recently published their findings in the journal Scientific Reports, shedding valuable light on the neural mechanism through which cannabis activates a specific cluster of neurons in the hypothalamus region of the brain, resulting in an increased stimulation of appetite.

The hunger-inducing effects of marijuana are well-known among consumers. However, recent findings from animal research provide valuable insights that could potentially lead to targeted therapeutics for addressing conditions such as anorexia.

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After exposing mice to vaporized cannabis, the researchers utilized calcium imaging technology, akin to a brain MRI, to monitor the changes in neuron activity. Through their investigation, they discovered that marijuana vapor attached to cannabinoid-1 receptors in the brain and activated Agouti Related Protein neurons in the hypothalamus, commonly known as “feeding” neurons.

Calcium imaging has been used to study the brain’s reactions to food by other researchers, but this is the first known study to use it to understand those features following cannabis exposure.

As part of this research, it was discovered that the cannabinoid-1 receptor, which is a target of cannabis, regulates the activity of Agouti Related Protein neurons. These particular neurons are well-known for their involvement in controlling feeding behavior and are located in the hypothalamus. This finding sheds light on the intricate connection between the cannabinoid system and the regulation of these essential cells in the brain.

With the help of this information, scientists employed a “chemogenetic” technique, acting as a molecular light switch, to specifically target these neurons in animals exposed to cannabis. By deactivating these neurons, the appetite-stimulating effects of cannabis were no longer present.

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“We now know one of the ways that the brain responds to recreational-type cannabis to promote appetite,” said Davis.

This work builds on previous research on cannabis and appetite from Davis’ lab, which was among the first to use whole vaporized cannabis plant matter in animal studies instead of injected THC—in an effort to better mimic how cannabis is used by humans.  

In the previous study, researchers discovered genetic alterations in the hypothalamus as a response to cannabis. Therefore, in this investigation, Davis and his colleagues specifically concentrated on this particular region.

Now tell us why it makes food taste so much better!

Read more here – Cannabis activates specific hunger neurons in brain

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